A study of topical treatment with Hialsorb Sport in sportspeople with gonalgia knee pain, using high-resolution ultrasound scans to evaluate response.
Study details
No. of sportspeople: 60
Study duration: 2 months
METHOD
The study was carried out on 60 patients with knee pain who were beginning rehabilitation treatment.
Patient details recorded included: - Lequesne's questionnaire: measurements of functional capacity (movement).
- Patients' age, sex, weight and height, along with details of any analgesics or NSAIDs taken orally.
The 60 patients were divided into two groups: 30 received only rehabilitation treatment given by a physiotherapist, while the other 30 also had Hialsorb Sport massaged into their knees by the physiotherapist at every session. The functional capacity of each knee was measured once more in accordance with the Lequesne Index after 20 sessions.
High-resolution ultrasound scans were performed on all patients at the start of treatment, followed by a scan after one month and another after two months. Each scan checked for the presence of water on the knee, synovitis, tendinosis, bursitis, Baker's cyst and for the power Doppler signal.
Paracetamol was used as a rescue medication.(*)
(*) Rescue medication. The protocols of clinical trials usually provide for the use of rescue medication (an effective, well-known, commonly used analgesic drug that is not included for comparison purposes in the trial) if the clinical analgesic response is insufficient.
DIAGNOSIS - Prepatellar bursitis
- Quadricipital/patellar tendinosis
- Infrapatellar bursitis
- Baker's cyst
- No findings
The main criterion in terms of efficacy was functional capacity, measured in accordance with the Lequesne Index and by means of basal high-resolution ultrasound scan.
RESULTS
LEQUESNE INDEX:
Evaluation offunctional capacity
The Lequesne Index measures difficulty of movement when carrying out certain day-to-day activities, and at different times of the day.
* The higher the index, the greater the functional incapacity.
The results of the study indicated improvement in functional capacity (movement) in both groups. However, the improvement was much greater in the patient group that received topical massage with Hialsorb Sport during the physiotherapy sessions. - The patients who only received physiotherapy rehabilitation showed an improvement of 37% at the end of the treatment.
- The patients who received physiotherapy rehabilitation plus massage with Hialsorb Sport cream at each session showed an improvement of 70%.
|  | BASAL ULTRASOUND SCAN
Knee 1 - Deep infrapatellar bursitis.
- The power Doppler signal indicates there is inflammation in the joint area.
|  | FINAL ULTRASOUND SCAN
Knee 1 - Mild infrapatellar bursitis.
- No power Doppler signal indicates that the inflammation has been reduced noticeably.
|
GENERAL CONCLUSIONS
The results obtained from the study show that, thanks to its special composition, Hialsorb Sport cream provides effective relief to joints, improves mobility and reduces the discomfort associated with joint problems.
Hialsorb Sport is an effective treatment for knee pain caused by joint-cartilage loss and/or softtissue injuries such as tendinosis and bursitis, when diagnosed by ultrasound.
TOPICAL APPLICATION OF HIALSORB SPORT WAS SHOWN TO ENHANCE THE EFFECTS OF PHYSIOTHERAPY AND SPEED UP FUNCTIONAL RECOVERY.
Transdermal permeation study of HIALSORB SPORT cream
Laboratory of the Biopharmaceutical and Pharmacokinetic Research Unit (UIBF) of the Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Barcelona. 2005.
The mean permeation values at the different appearance times (2, 5, 22, 23 and 24 hours after application) are shown in the following graph, from which it can be seen that the highest coefficient was reached 24 hours after application.
CONCLUSIONS
Based on the results of this study, it is recommended that Hialsorb Sport cream should be massaged the joint once or twice a day into day. |
