| Heparin was discovered by Mac Lean in 1916. It has been medically important as an anticoagulant since its introduction over a half-century ago, and recently a number of new biological activities has been adscribed to it.
Heparin is a very complex glycosaminoglycan composed of alternate sequences of uronic acid (usually -L-iduronic acid) and -D-glucosamine linked by (14)bonds, with sulphate groups in the glucosamine ring.
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Heparin is polydisperse in chain length and heterogeneous in degree and type of sulfatation.
| CAS NO. 9041-08-1
EINECS NO. 2326817 | |
Heparin possesses numerous activities, but the most important is its anticoagulant property.
Heparin forms a complex with Antithrombin III, and inhibits
several activated blood coagulation factors: XIIa, XIa, Xa, IIa, Thrombin and
Kallikrein.
It is also used as a thrombolytic, fat-clearing antiartherosclerotic and as a
pottentially effective antiinflammatory agent.
- Acute phase myocardial infartus.
- Prophylactic and curative treatment of venous and arterial thromboembolism.
- Pulmonary embolism.
- Prevention of pulmonary thromboembolism and deep venous thrombosis in pregnancy.
- Peripheral obliterative arterial diseases.
- Atherosclerosis.
- Extra-corporeal circulation (ECC).
- Hemodyalisis.
- Extra-corporeal therapies, such as heart-lung oxygenation and kidney dialysis.
- Open heart surgeries.
- Deep phlebitis.
- Vitreoretinal surgery.
- Topical application on flap survival.
- Topical application for leg ulcers.
A wide range of novel biological activities have recently been under research. Due to their structural complexity and high capacity of biological interaction, Heparin and its derivates are molecules with a huge potential for the development of novel drugs. The activity of Heparin is currently being studied in the treatment of numerous diseases: · Cancer
· Chronic obstructive pulmonary disease (COPD)
· Organ transplants
· Allergic encephalomyelitis
· Allergic rhinitis
· Arthritis
· Asthma
· Irritable bowel syndrome
· Pulmonary emphysema
· Interstitial cystitis Many of these studies are in an advanced stage of clinical development, and some of them are supported by Bioiberica Heparin Science.
Packed in three plastic bags inside a metal drum weighing 2, 10, 25 and 80 Kg, depending on order quantity.
Heparin is currently available in bulk quantities. It is presented in solid powder form. The qualities available are: - Sodium heparin
- Lithium heparin
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