Specialists in biomolecules
Hyaluronic acid is a non-sulfated glycosaminoglicane formed by repetitions of the disaccharide N-acetylglucosamine and N-glucuronic acid. Of a viscous texture, it exists in the synovial liquid, vitreal humor and connective tissue of a number of organisms. In human beings it is concentrated in the joints and the skin. An average man of 70 kilograms weight can have a total quantity of 15 grams of hyaluronic acid in his body and one third of this is broken down and synthesized every day.
It is formed by chains of complex carbohydrates , specifically 50 000 N-acetylglucosamine disaccharides and N-glucuronic acid per molecule. This chain forms spirals with an average molecular weight of 2 to 4 million. It has the property of retaining great quantities of water and adopts an extended form by dissolution, and therefore has viscoelastic properties. These properties are achieved due to the large number of OH groups and negative charges of this molecule, which enables the carbohydrate chains to be kept relatively separate from each other, due to the establishment of repulsive forces.
Thanks to its viscoelastic properties, hyaluronic acid acts as a biological lubricant in various tissues, including synovial liquid in the joints. In patients with osteoarthrisis, the hyaluronic acid in the synovial liquid depolymerizes, the result being a decrease in molecular weight and viscoelasticity, increasing the cartilage's susceptibility to lesion.
Due to its physical-chemical characteristics, hyaluronic acid has various clinical applications. It is most widely used in the cosmetics field, as hydrating and anti-aging agent. It is also used in plastic surgery as a biomaterial filler. In ophthalmology it is used in eye surgery and as a lubricant in certain eye diseases. In joint medicine it is used as a viscosupplement, by means of intra-articular injections, to recover the viscoelastic properties of the synovial liquid of patients with osteoarthritis. A number of clinical trials demonstrate that it has clinical benefits for reducing pain and improving the joint's functional capacity. Hyaluronic acid injections are also applied for recovery from lesions in soft tissue, such as tendons and ligaments.
As a drug, hyaluronic acid belongs to the M09AX group: Other drugs for muscular-skeletal problems (ATC -Anatomic Therapeutic Chemical Classification of the World Health Organisation).
Hyaluronic acid produced by Bioibérica
Bioibérica produces hyaluronic acid of great purity from cockscomb, available in different molecular weights/viscosities and suitable for any commercial application.
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