We Participate in a Revolutionary New Project to Heal and Regenerate Skin: Biopen4Reg

We are part of a revolutionary advance in regenerative medicine applied to skin, the new Biopen4Reg. With this device, we have achieved a manual bioprinting development inspired by an airbrush that applies regenerative bioinks directly onto skin wounds.

Bioprinting with regenerative biogels

Biopen4Reg accelerates the wound healing process. It achieves a dense dermis and stratified epidermis, with hydration, elasticity, and pigmentation properties similar to healthy skin. Additionally, it avoids the risks associated with traditional grafts.

Biopen4Reg manual bioprinting device for skin regeneration with bioinks containing collagen, elastin, and hyaluronic acid.

Biotechnology is transforming the way we understand health and wellbeing. Thanks to research and collaboration between scientific institutions and companies, we are getting closer to solutions that not only treat diseases, but also regenerate tissues and restore quality of life to people. At Bioiberica, we are proud to have participated in an innovative project in dermal regenerative medicine: the new Biopen4Reg.

What is Biopen4Reg?

It is a portable manual bioprinting device capable of applying regenerative biogels directly onto damaged skin, developed jointly with the University of Granada, the Virgen de las Nieves University Hospital, the University of Jaén, as well as the BioFab i3D, F2N2Lab research groups and the Modeling Nature (MNat) Unit.

Biopen4Reg accelerates the wound healing process, achieving a dense dermis and stratified epidermis, with hydration, elasticity, and pigmentation properties similar to healthy skin. All this while avoiding the risks associated with traditional grafts.

Inspired by an airbrush, it applies regenerative bioinks directly onto skin wounds. These bioinks are composed of key molecules for regeneration, such as:

Collagen, which provides structure and support to the tissue.
Elastin, which provides elasticity and resistance.
Hyaluronic acid, which promotes hydration and creates an optimal environment for regeneration.
Keratin, essential for the formation of a functional epidermis.

The result is the creation of high-quality new skin tissue, capable of significantly reducing healing time and avoiding complications associated with traditional grafts.

Accelerating wound healing

Biopen4Reg marks a promising path for its future clinical application in people who have suffered severe skin injuries or burns.

A successfully proven advance

In the first trials on animal models, Biopen4Reg managed to accelerate wound healing, resulting in a dense dermis and stratified epidermis, with properties similar to healthy skin in terms of hydration, elasticity, and pigmentation. All this while reducing risks and complications compared to conventional techniques.

This milestone not only confirms the potential of the biogel and device, but also marks a promising path for its future clinical application in people who have suffered severe skin injuries or burns.

Our Commitment to Health Innovation

This represents another step in our commitment to research and development of biomedical solutions that improve people's quality of life. An advance that demonstrates how collaboration and innovation can transform the future of health.

We believe that science is the engine of change. This project reinforces our commitment to applied biomedical research and to the development of solutions that transform the future of medicine.

Our role in Biopen4Reg has been to provide expertise in the design and development of key biocomponents for regeneration, such as collagen and glycosaminoglycans. A contribution that reflects our mission: to improve people's quality of life through biotechnology.

Collaborative innovation

This advance demonstrates how interdisciplinary collaboration (universities, research centers, and biotechnology companies) accelerates the development of innovations.

Biopen4Reg spraying system. D) Schematic representation of the spray nozzles. E) Metabolic activity, measured as fluorescence intensity (AU), of hDFs sprayed at different pressures = 4 per condition) in FibD hydrogels at days 1, 2, 3, 5, and 7. Statistical analysis was performed using an ANOVA test, followed by Tukey's post-hoc test. (© 2025 The Author(s). Advanced Healthcare Materials published by Wiley-VCH GmbH.)

Looking to the Future of Regenerative Medicine

Biopen4Reg is a statement of intent about the future of the most personalized and regenerative skin medicine.

This advance demonstrates how interdisciplinary collaboration—universities, research centers, and biotechnology companies—can accelerate the development of innovations that seemed unthinkable a few years ago.

At Bioiberica, we will continue to support initiatives that, like this one, open new possibilities for human health and consolidate biotechnology as a pillar of global wellbeing.

Bibliography

Universidad de Granada. “Desarrollan un dispositivo de bioimpresión manual que acelera la regeneración de heridas cutáneas”. Canal UGR.
Good4Good. “Revolución médica: diseñan un biogel que imita y cura la piel”. Good4Good.
Advanced Healthcare Materials "A Novel Sprayable Fibrinogen/Glycosaminoglycans/Collagen-Based Bioink for Skin Wound Healing Applied by a Handheld Dual-Head Airbrush"

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