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Nucleoforce Aqua

"The bricks of life"

What is it? What is it for?

Nucleoforce Aqua™is a balanced concentrate of free nucleotides and active precursors, obtained from yeasts.             

The exclusive composition of Nucleoforce Aqua™ has been designed to precisely and specifically meet the needs of fish and crustaceans, helping the optimal development of the immune and digestive systems.

Thanks to its exceptional characteristics, it minimises the intestinal inflammatory response in diets rich in raw vegetable materials, helping to strengthen digestibility and thus improve the animals' intestinal health.


Principal effects in fish and crustaceans

In fish:

  • Development of the immune system 1,2,7.
  • Development of the digestive system 1,2,3.
  • Resistance to diseases 1,4,6.
  • Lower mortality 1,4.
  • Increased vaccine response 4.
  • Increased survival rate 8
  • Increased egg production 9


1. Rasha M.Reda, Khaled M.Selimb, Iman E.El-Araby. Effect of dietary yeast nucleotide on antioxidant activity, non-specific immunity, intestinal cytokines, and disease resistance in Nile Tilapia. Fish and Shellfish Immunology 2018.

2. Borda E., Estevez A., Tort L., Chetrit C. Effect of free nucleotides on the immune response during the first stage of fattening in gilthead bream. Aquaculture Europe 2005.

3. Saenz de Rodrigañez M.A., Barata M., Dias J., Pousao-Ferreira P., Morales G.A., Marquez L., Moyano F.J., Ribeiro L. Evaluation of the effect of nucleotides on intestinal function in juveniles of meagre (Agrysomus regius) fed on high plant protein diets. Aquaculture Europe, 2012.

4. Borda E., Chetrit C., De La Fuente E. Efficacty of dietary nucleotides supplementation on the immune response in Atlantic Salmon (Salmo Salar). Effects on salt water transfer and vaccination. Aquaculture Europe, 2008.

5. Effect of the dietary nucleotide supplement on the survival rate of Litopenaeus Vannamei. CENAIM, ESPOL, ECUADOR (2014).

6. Immunity and growth performance of giant tiger prawn as influenced by dietary nucleotide supplement (Penaeus Monodon Fabricius). Rey Antonio Belleta Blaya, BS Biology, Marine Biology, Department of Biological Sciences, Visayas State University. The Philippines, 2009. 

7. Effect of the dietary nucleotide supplement on the survival rate of Giant Tiger Prawn (Penaeus Monodon Fabricius). Rhex Morata Relente, BS Bioloby. Marine Biology, Department of Biological Sciences, Visayas State University. The Philippines, 2009. 

8. Effect of the use of Nucleoforce Shrimps LR in diets of Penaeus Vannamei whiteleg shrimp reproducers. Merchan Fontana 2019.

Product Information


Cream-coloured powder product with characteristic flavour and aroma.



The recommended dose is 500 ppm in fish and shrimp diets.

Frequently asked questions about Nucleotides

What are nucleotides?

They are semi-essential nutrients, which are characterised as being the structural unit of the cell's nucleic acids. Their molecular composition is made up of a sugar, a nitrogen base and one to three phosphate groups.


Why are they semi-essential nutrients?

Eggs and milk are substances that are naturally rich in nucleotides, providing young animals a source of nucleotides available for tissues with minimal capacity for de novo synthesis.


Main effects that they cause in animals

Nucleotides are particular necessary for the development of tissues with a high rate of cellular reproduction, such as the reproductive, immune, and digestive systems.

They play an important role in situations in which the animals needs are not covered only with de novo or endogenous synthesis.