You are here



What is it? What is it for?

IMPROMUNE® is a food supplement recommended for cats and dogs to strengthen their immune systems and to boost any innate or adaptive response (2).

Nucleoforce® is a specific Nucleotide formulation developed after studying the specific needs of different species of mammals. Nucleotides are semi-essential immunonutrients which, when taken orally, contribute to the correct development of the immune system.

Nucleoforce® regulates phagocytic activity of macrophages as well as the interaction between these and T lymphocytes. It also regulates the maturation, proliferation and activity of T lymphocytes. AHCC® is an extract from the mycelium of Lentinus edodes, which regulates NK cell activity, as well as macrophage proliferation and differentiation of T to Th1 lymphocytes.

Different studies have shown that in combination, Nucleoforce® and AHCC® have a synergic effect that acts on innate and adaptive responses.

This synergic effect has been patented.


1- PetSellout report March 2020.
2- Evangelio Sánchez E., Borda E., Tecles Vicente F., Martínez-Puig D., Cerón Madrigal J.J., Chetrit, C. 10th Congress of The European Society of Veterinary clinical Pathology, Barcelona, 2008.



Each palatable tablet contains:

Nucleoforce® (Yeast extract S. cerevisiae with Nucleotides)


AHCC® (Lentinus edodes, mushroom)

315 mg

Magnesium stearate



Storage conditions

Keep in a cool, dry place.


Dosage and form of administration

Administering IMPROMUNE® is easy thanks to its great palatability. Due to its design, the tablets can be divided to make it easier for smaller animals to swallow them. Depending on the case and the animal’s progression, the administration period can be lengthened according to the veterinarian's instructions.

Anim​al weight

Daily tablets

<10 kg 1/2
11-25 kg 1
>26 kg 2

IMPROMUNE® does not cause adverse effects.


Recommended use (3,4,5)



Infectious processes:

• Bacteria (e.g. pyogenic infection), viruses (e.g. calicivirus, papillomatosis), Parasites (e.g.: demodicosis, giardia), fungal infections (e.g.: ringworm, Malassezia)

• Leishmania


Minimum duration 15-20 days


Minimum duration 6 months


Acquired immunosuppression:

• Administration of immunosuppressants (e.g. glucocorticoids)

• Chemotherapy

• Elderly animals, immunosenescence

• Stress:

Postoperative/post-multiple trauma conditions (e.g. Caesarean section, pyometra)

Reproduction (e.g. lactation, large litters) Puppies (e.g.: around vaccine period)


Before and after treatment, 15-20 days

Before, during and after chemotherapy, 15-20 days

Minimum duration 30 days



Minimum duration 30 days

Minimum duration 30 days

Minimum duration 30 days



In packs of 20 or 40 tablets, boxes of 200 tablets.

Each clinical package contains: 20 blister packs of 10 tablets or 12 dispenser sachets.



3, Romano V, Martínez-Puig D, Torre C, Iraculis N, Vilaseca LI, Chetrit C, Journal of Animal Physiology and Animal Nutrition Journal compilation, 2007.
4, Segarra S, Miró G, Montoya A, et al. Randomized, allopurinol-controlled trial of the effects of dietary nucleotides and active hexose correlated compound in the treatment of canine leishmaniosis, Vet Parasitol, 2017;239:50-56.
5, Segarra S, Miró G, Montoya A, Pardo-Marín L, Teichenné J, Ferrer L, Cerón JJ, Prevention of disease progression in Leishmania infantum-infected dogs with dietary nucleotides and active hexose correlated compound, Parasit
Vectors. 2018 Feb 21;11(1):103.