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A genetic test for osteoarthritis

28 Jun 2015

We're accompanying Mari Carmen to pick up the results of her Arthrotest, the genetic test for osteoarthritis. Her quality of life depends on them...

Mari Carmen de la Osa

  • Osteoarthritis is a chronic disease causing pain and restricting mobility

My name is Mari Carmen de la Osa Escudero, I'm 46, I've got polyosteoarthritis in several joints of my body, which are fairly painful. I'm completely and utterly restricted in my day-to-day routines, in my  job, at home, everything. At home just doing the most normal stuff in the world like doing the cleaning, tidying, bending down is a triumph for me as I can't even bend down now. In my job, I'm an auxiliary nurse, I'm really restricted because some days I can't even get out of bed. I'm really scared about not being able to  move about in the future, about getting really ill.

  • Arthrotest is the first DNA test to ascertain the progression of osteoarthritis of the knee.

The doctor called me one day and told me about the new test and whether I wanted to take the genetic test and I told her I would be glad to.

Dr Santiago Palacios, Director of Centro Médico Instituto Palacios, Salud y Medicina de la Mujer

  • Analysing saliva can reveal genetic disorders associated to the rapid progression of the disease.

We offered her the chance to find out the genetic risk she had of developing severe osteoarthritis, with a greater risk of having a prosthesis. What Arthrotest shows us, as well as being genetic-based, is whether she is going to have severe osteoarthritis, so we need to take very robust measures as her prognosis is at the very least worrying, or whether it is osteoarthritis that possibly, with exclusively preventive measures such as chondoprotection and hygiene, we can make its progression more gradual and slower, giving her a good quality of life.

So Mari Carmen, you've come to pick your results up, haven't you? Yes. Well, let's have a look at them...Result: look at this, it's good news. The patient's genetic predisposition of developing osteoarthritis of the knee rapidly is low.

  • The doctor can personalise treatment will the results

We're going to give you a medicine called a chondroprotector. What it does is protect your cartilage and make its destruction much slower. This will make the progression of your osteoarthritis much slower and it will also take away the pain so that you will need fewer anti-inflammatory drugs, which is great news for us.

Mari Carmen de la Osa

How did it go? Great, I'm really happy, I've got good genetics and I feel a lot calmer now. Much calmer knowing I'm not going to have to use a prosthesis in the near future.