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Bioiberica Heaprine Dermatan

Dermatan sulfate

Natural glycosaminoglycan

Dermatan sulfate, also known as chondroitin sulfate B, is found in a wide range of tissues and in virtually all animals. It is obtained by biochemical extraction and purification.

What is it? What is it for?

Potential therapeutic applications

Anticoagulant and antithrombotic activity:

A well-studied interaction of dermatan is the binding of dermatan sulfate to heparin cofactor II, which acts by inhibiting the procoagulant activity of thrombin. It has been reported that this inhibitory effect increases a thousand-fold in the presence of dermatan sulfate.

 

Dermatan sulfate in wound repair:

As is well known, dermatan sulfate is an important component of the skin and, bearing in mind its location and activities related to coagulation, cell growth and its ability to interact with several proteins, the role of dermatan sulfate in wound repair is currently a very active area of research.

 

Dermatan sulfate in infectious processes:

Dermatan sulfate (and related proteoglycans) have been associated with the ability to increase resistance to infectious diseases.

 

Dermatan sulfate in the central nervous system:

The central nervous system is a rich and complex source of proteoglycans consisting, amongst others, of dermatan sulfate and chains of chondroitin sulfate. Particularly high levels of chondroitin sulfate and dermatan sulfate proteoglycans have been seen during brain development. Their presence is related to regulation of expression of growth patterns, which suggests important functions in all developmental stages.

 

Dermatan sulfate as a potential anticancer drug:

A clear correlation has been shown between the accumulation of chondroitin sulfate and dermatan sulfate proteoglycans and cancer progression. Dermatan sulfate interacts with many growth factors and cytokines involved in cancer formation and progression. As a consequence, structural changes in dermatan sulfate chains and their properties may influence cancer cell biology, growth, and migration. The specific sequences that bind to several key proteins have yet to be identified, but their research and characterization may lead to molecular targets for cancer diagnosis and treatment.

Specifications
Storage and Packaging

Storage and handling conditions

The product does not require special storage conditions, however we recommend that it be kept in a cool, dry place preferably at temperatures below 40ºC.

Handling Instructions

Wear a dust mask, gloves and safety goggles.

Packaging

The API as white powder is triple-packed in polyethylene bags sealed with a polyamide cable tie for drums and cans.

The product is available in the following containers according to the quantity and customer specifications:

  • Drums of 60L, 30L, 2L , 15 ml vial and 100ml vial.
  • The weight limit of our drums is 20 kg net.
  • All the containers are fitted with security seals to prevent any potential tampering.
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