It’s more than an API — it’s a lifeline. Saves more than 100 million lives every year and is considered an essential medicine by the World Health Organisation.
The heparin molecule and its derivatives show enormous potential for the development of new drugs and applications. We are actively exploring this in close partnership with leading laboratories and research centres worldwide, aiming to unlock the full potential of this life-saving molecule.
Heparin – Life Flows in You
What is Dermatan sulfate?
Dermatan sulfate, also known as chondroitin sulfate B, is a natural glycosaminoglycan mainly found in the skin, but also in blood vessels, heart valves, tendons, lungs, and intestinal mucosa. It is present in the bodies of virtually all animals and is obtained via biochemical extraction and purification.
In addition to its vital structural role in tissues and organs, dermatan sulfate is thought to be involved in wound repair, the regulation of blood coagulation and infection response, although its role in these latter processes has not been fully characterized. Thanks to its key applications in cell differentiation, morphogenesis, and migration, dermatan sulfate is also widely used in the cosmetics industry, and its potential clinical applications could be even more significant.
Potential therapeutic applications
Anticoagulant and antithrombotic activity
A well-studied interaction of dermatan is the binding of dermatan sulfate to heparin cofactor II, which acts by inhibiting the procoagulant activity of thrombin. It has been reported that this inhibitory effect increases a thousand-fold in the presence of dermatan sulfate.Wound repair
As an important component of skin with activities related to coagulation, cell growth and interaction with several proteins, exploring dermatan sulfate as a support for wound repair is currently a very active area of research.Infectious disease response
Dermatan sulfate (and related proteoglycans) have been linked to an increased resistance to infectious diseases.Central nervous system function
The central nervous system is a rich and complex source of proteoglycans, including dermatan sulfate and chains of chondroitin sulfate. Particularly high levels of these proteoglycans have been observed during brain development relating to the regulation and expression of growth patterns, pointing to important functions at all developmental stages.Potential as an anticancer drug
Dermatan sulfate interacts with many growth factors and cytokines involved in cancer formation and progression. As a consequence, structural changes in dermatan sulfate chains and their properties may influence cancer cell biology, growth, and migration. The specific sequences capable of binding to key proteins are to be identified, but their characterization may lead to molecular targets for cancer diagnosis and treatment.
Specifications
As a leading dermatan sulfate manufacturer, our meticulous production process allows us to deliver high-purity ingredients with a standard dermatan sulfate content far in excess of 90%, and even higher percentages available on request for research purposes. Thanks to this commitment to quality, the European Directorate for the Quality of Medicines & Healthcare (EDQM) selected Bioiberica as the reference supplier of dermatan sulfate across its jurisdiction. Find out more about our reference-standard ingredient in our dermatan sulfate specification sheet.
Heparin material safety sheet
Get the precise technical and safety data you need for our entire high-quality heparin portfolio.
Storage and packing
Storage and handling conditions
Our dermatan sulfate product does not require special storage conditions, however we recommend that it be kept in a cool, dry place, preferably at temperatures below 40ºC.
Handling instructions
Wear a dust mask, gloves and safety goggles.
Packaging
The API is sold as a white powder, triple-packed in polyethylene bags and sealed with a polyamide cable tie for drums and cans.
The product is available in the following containers according to quantity and customer specifications:
Drums of 60L, 30L and 2L, 100ml and 15ml vials.
The weight limit of our drums is 20 kg net.
All the containers are fitted with security seals to prevent any potential tampering.
Pioneering pharmaceutical excellence
With full visibility of our vertically integrated supply chain and industry-leading production standards, we deliver quality-assured health and nutrition solutions that are as reliable as they are powerful.
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