It’s more than an API — it’s a lifeline. Saves more than 100 million lives every year and is considered an essential medicine by the World Health Organisation.
The heparin molecule and its derivatives show enormous potential for the development of new drugs and applications. We are actively exploring this in close partnership with leading laboratories and research centres worldwide, aiming to unlock the full potential of this life-saving molecule.
Heparin – Life Flows in You
What is heparin sodium?
Heparin sodium belongs to the family of glycosaminoglycans, a group of linear polysaccharides with a negative charge formed by alternating repeating units of an amino sugar and a uronic acid.
In the case of heparin, the amino sugar is D-glucosamine (N-acetylated or N-sulfated), while the uronic acid may be L-iduronic acid or D-glucuronic acid.
With a high safety and confidence profile, heparin sodium is a widely tested active pharmaceutical ingredient (API) that exhibits multiple biological activities. It’s most famous for its anticoagulant properties, an activity made possible by its interaction with coagulation-inhibiting blood proteins such as antithrombin III (ATIII). Here, heparin acts as catalyst, accelerating the speed at which ATIII inhibits various procoagulant proteins, notably factors Xa and IIa (Thrombin). In this way, heparin prevents the formation of fibrin, one of the key components of a blood clot.
Potential therapeutic applications
For the treatment of:
Acute myocardial infarction
Prophylactic and curative treatment of arterial and venous thromboembolism
Pulmonary embolism
Prevention of pulmonary and deep venous thromboembolism during pregnancy
Peripheral artery diseases
Atherosclerosis
Extracorporeal circulation (ECC)
Anticoagulant coating for medical devices
Hemodialysis
Extracorporeal therapies such as heart-lung oxygenation and hepatic dialysis
Open heart surgery
Deep phlebitis
Vitreoretinal surgery
Topical applications for ulcer treatment
Topical applications for treatment of varices
New research
A large number of new biological activities are currently being investigated. Because of its structural complexity and its great biological interaction capacity, heparin and its derivatives are molecules with huge potential for development of new drugs. The activity of heparin sodium is currently being studied in the treatment of a wide range of diseases, including:
Cancer
Chronic obstructive pulmonary disease (COPD)
Organ transplantation
Allergic encephalomyelitis
Allergic rhinitis
Arthritis
Asthma
Irritable bowel syndrome
Pulmonary emphysema
Interstitial cystitis
Cystic fibrosis
Malaria
Inflammatory syndromes
Burns
Ischemia
Ulcerative colitis
Heparin sodium: Specification
Our heparin sodium API complies with EP, USP, and JP monographs.
It is a product of 100% porcine origin, sourced from Europe, North America, and South America.
It is classed as unfractionated heparin with a molecular weight between 15,000 and 19,000 Dalton.
Our production process for all heparin APIs is certified by GMP and inspected by the USFDA.
CAS No. 9041-08-1
EP Specification > Download
USP Specification > Download
JP Specification > Download
Heparin material safety sheet
Get the precise technical and safety data you need for our entire high-quality heparin portfolio.
Storage and packing
Storage and handling conditions
Our heparin sodium product does not require special storage conditions, however we recommend that it be kept in a cool, dry place, preferably at temperatures below 40ºC.
Handling instructions
Wear dust mask, gloves and goggles.
Packaging
The API as white powder is triple-packed in polyethylene bags sealed with a polyamide cable tie for drums and cans.
The product is available in the following containers according to quantity and customer specifications:
Drums of 60L, 30L and 2L, 100ml and 15ml vials.
The weight limit of our drums is 20 kg net.
All the containers are fitted with security seals to prevent any potential tampering.
Pioneering pharmaceutical excellence
With full visibility of our vertically integrated supply chain and industry-leading production standards, we deliver quality-assured health and nutrition solutions that are as reliable, as they are powerful.
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